Purification notesPurified from rabbit serum by epitope-specific affinity chromatography. The antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated PED/PEA-15. The final product is generated by affinity chromatography using a PED/PEA-15-derived peptide that is phosphorylated at serine 116.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Detects a band of approximately 15 kDa (predicted molecular weight: 15 kDa).
FunctionBlocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
Tissue specificityUbiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
15 kDa phosphoprotein enriched in astrocytes antibody
Astrocytic phosphoprotein PEA 15 antibody
Astrocytic phosphoprotein PEA-15 antibody
Astrocytic phosphoprotein PEA15 antibody
HMAT 1 antibody
Homolog of mouse MAT 1 oncogene antibody
Homolog of mouse MAT1 oncogene antibody
HUMMAT 1H antibody
MAT 1 antibody
MAT 1H antibody
PEA 15 antibody
PEA15 protein antibody
Phosphoprotein enriched in astrocytes 15 antibody
Phosphoprotein enriched in astrocytes 15kD antibody
Phosphoprotein enriched in diabetes antibody
References for Anti-PEA15 (phospho S116) antibody (ab18032)
This product has been referenced in:
Mielgo A et al. Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. Oncogene28:3551-62 (2009).
Read more (PubMed: 19668227) »
Callejas-Valera JL et al. E1a Gene Expression Blocks the ERK1/2 Signaling Pathway by Promoting Nuclear Localization and MKP Up-regulation: IMPLICATION IN v-H-Ras-INDUCED SENESCENCE. J Biol Chem283:13450-8 (2008).
Read more (PubMed: 18316372) »