Overview

  • Product nameAnti-PEAR1 antibody
  • Description
    Rabbit polyclonal to PEAR1
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: PSDPNTCSFW ESFTTTTKES HSRPFSLLPS EPCERPWEGP HTCPQPTVVY RTVYRQVVKT DHRQRLQCCH GFYES, corresponding to amino acids 23-97 of Human.

  • Positive control
    • Human bone marrow tissue.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferpH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab122261 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionWhen overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
  • Tissue specificityExpressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.
  • Sequence similaritiesBelongs to the MEGF family.
    Contains 9 EGF-like domains.
    Contains 1 EMI domain.
  • Post-translational
    modifications
    Phosphorylated in the intracellular domain on tyrosine residues (By similarity). Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2.
  • Cellular localizationCell membrane. Detected on the cell surface in resting platelets.
  • Information by UniProt
  • Database links
  • Alternative names
    • hPEAR1 antibody
    • JEDI antibody
    • MEGF12 antibody
    • Multiple EGF-like domains protein 12 antibody
    • Multiple epidermal growth factor-like domains protein 12 antibody
    • Pear1 antibody
    • PEAR1_HUMAN antibody
    • Platelet endothelial aggregation receptor 1 antibody
    • RP11-107D16.3 antibody
    see all

Anti-PEAR1 antibody images

  • ab122261, at 1/35, staining PEAR1 in paraffin embedded Human bone marrow tissue by Immunohistochemistry.

References for Anti-PEAR1 antibody (ab122261)

ab122261 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"