• Product nameAnti-PEDF antibody
    See all PEDF primary antibodies
  • Description
    Rabbit polyclonal to PEDF
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human PEDF.

    (Peptide available as ab74438.)

  • Positive control
    • This antibody gave a positive signal in the following Human Tissue lysates: Plasma Total Protein Lysate, Kidney, Ovary (data not shown), Skeletal Muscle (data not shown).



Our Abpromise guarantee covers the use of ab74439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1 µg/ml. Detects a band of approximately 46 kDa (predicted molecular weight: 46 kDa).
    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionNeurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
    • Tissue specificityRetinal pigment epithelial cells and blood plasma.
    • Sequence similaritiesBelongs to the serpin family.
    • Developmental stageExpressed in quiescent cells.
    • DomainThe N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.
    • Post-translational
      The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.
      N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
    • Cellular localizationSecreted. Melanosome. Enriched in stage I melanosomes.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cell proliferation-inducing gene 35 protein antibody
      • EPC 1 antibody
      • EPC-1 antibody
      • EPC1 antibody
      • OI12 antibody
      • OI6 antibody
      • PEDF antibody
      • PEDF_HUMAN antibody
      • PIG 35 antibody
      • PIG35 antibody
      • Pigment epithelium derived factor antibody
      • Pigment epithelium-derived factor antibody
      • Proliferation inducing protein 35 antibody
      • serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 antibody
      • Serpin F1 antibody
      • Serpin family F member 1 antibody
      • Serpin peptidase inhibitor clade F member 1 antibody
      • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 antibody
      • SERPINF 1 antibody
      • Serpinf1 antibody
      see all

    Anti-PEDF antibody images

    • All lanes : Anti-PEDF antibody (ab74439) at 1 µg/ml

      Lane 1 : Human Plasma Total Protein Lysate
      Lane 2 : Human kidney tissue lysate - total protein (ab30203)

      Lysates/proteins at 10 µg per lane.

      Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

      Performed under reducing conditions.

      Predicted band size : 46 kDa
      Observed band size : 46 kDa
      Additional bands at : 150 kDa. We are unsure as to the identity of these extra bands.

      Exposure time : 30 seconds

    References for Anti-PEDF antibody (ab74439)

    ab74439 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab74439.
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