The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 43 kDa.
FunctionRequired for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity.
Tissue specificityUbiquitously expressed.
Sequence similaritiesBelongs to the eukaryotic release factor 1 family. Pelota subfamily.
DomainThe N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity.