Anti-PEN2 antibody (ab109619)


  • Product nameAnti-PEN2 antibody
    See all PEN2 primary antibodies
  • Description
    Rabbit polyclonal to PEN2
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    KLH conjugated synthetic peptide of 13 amino acids in length from near the N-terminus of Human PEN2.

  • Positive control
    • A20 cell lysate, Human adrenal, placenta and thymus tissue


Associated products


Our Abpromise guarantee covers the use of ab109619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 12 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionEssential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
  • Tissue specificityWidely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
  • Sequence similaritiesBelongs to the PEN-2 family.
  • Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
  • Information by UniProt
  • Database links
  • Alternative names
    • Gamma secretase subunit PEN 2 antibody
    • Gamma Secretase Subunit PEN2 antibody
    • Gamma-secretase subunit PEN-2 antibody
    • Hematopoietic stem/progenitor cells protein MDS033 antibody
    • MDS033 antibody
    • MSTP064 antibody
    • PEN 2 antibody
    • PEN2_HUMAN antibody
    • Presenilin Enhancer 2 antibody
    • Presenilin enhancer 2 homolog antibody
    • Presenilin enhancer protein 2 antibody
    • PSEN2 antibody
    • psenen antibody
    see all

Anti-PEN2 antibody images

  • Lane 1 : Anti-PEN2 antibody (ab109619) at 0.5 µg/ml
    Lane 2 : Anti-PEN2 antibody (ab109619) at 1 µg/ml

    Lane 1 : A20 cell lysate
    Lane 2 : A20 cell lysate

    Predicted band size : 12 kDa
  • Human adrenal tissue (formalin-fixed, paraffin-embedded) stained with ab109619 at 5 µg/ml.
  • Human thymus tissue (formalin-fixed, paraffin-embedded) stained with ab109619 at 5 µg/ml.
  • Human placenta tissue (formalin-fixed, paraffin-embedded) stained with ab109619 at 5 µg/ml.

References for Anti-PEN2 antibody (ab109619)

ab109619 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step BSA as blocking agent for 10 minute(s) · Concentration: 1% · Temperature: 21°C
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Citric acid
Sample Human Tissue sections (Breast carcinoma)
Specification Breast carcinoma
Permeabilization No
Fixative Formaldehyde

Mr. Carl Hobbs

Verified customer

Submitted May 29 2013

Thank you for the additional information.

I can now confirm that the Anti-PEN2 antibody would bind N-terminal to the mutation at residue 23.

I hope that this information is helpful. Please do contact me if you have any additional q...

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Thank you for contacting us yesterday in regards to the Anti-Nicastrin antibody (ab45425) and Anti-PEN2 antibody (ab109619).

As discussed over the phone, I have requested further information regarding the immunogen used to raise the two antib...

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