Anti-PEN2 antibody (ab109619)


  • Product nameAnti-PEN2 antibody
    See all PEN2 primary antibodies
  • Description
    Rabbit polyclonal to PEN2
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    KLH conjugated synthetic peptide of 13 amino acids in length from near the N-terminus of Human PEN2.

  • Positive control
    • A20 cell lysate, Human adrenal, placenta and thymus tissue



Our Abpromise guarantee covers the use of ab109619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 12 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionEssential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
  • Tissue specificityWidely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
  • Sequence similaritiesBelongs to the PEN-2 family.
  • Cellular localizationEndoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
  • Information by UniProt
  • Database links
  • Alternative names
    • Gamma secretase subunit PEN 2 antibody
    • Gamma Secretase Subunit PEN2 antibody
    • Gamma-secretase subunit PEN-2 antibody
    • Hematopoietic stem/progenitor cells protein MDS033 antibody
    • MDS033 antibody
    • MSTP064 antibody
    • PEN 2 antibody
    • PEN2_HUMAN antibody
    • Presenilin Enhancer 2 antibody
    • Presenilin enhancer 2 homolog antibody
    • Presenilin enhancer protein 2 antibody
    • PSEN2 antibody
    • psenen antibody
    see all

Anti-PEN2 antibody images

  • Lane 1 : Anti-PEN2 antibody (ab109619) at 0.5 µg/ml
    Lane 2 : Anti-PEN2 antibody (ab109619) at 1 µg/ml

    Lane 1 : A20 cell lysate
    Lane 2 : A20 cell lysate

    Predicted band size : 12 kDa
  • Human adrenal tissue (formalin-fixed, paraffin-embedded) stained with ab109619 at 5 µg/ml.
  • Human thymus tissue (formalin-fixed, paraffin-embedded) stained with ab109619 at 5 µg/ml.
  • Human placenta tissue (formalin-fixed, paraffin-embedded) stained with ab109619 at 5 µg/ml.

References for Anti-PEN2 antibody (ab109619)

ab109619 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step BSA as blocking agent for 10 minute(s) · Concentration: 1% · Temperature: 21°C
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Citric acid
Sample Human Tissue sections (Breast carcinoma)
Specification Breast carcinoma
Permeabilization No
Fixative Formaldehyde

Mr. Carl Hobbs

Verified customer

Submitted May 29 2013

Thank you for the additional information.

I can now confirm that the Anti-PEN2 antibody would bind N-terminal to the mutation at residue 23.

I hope that this information is helpful. Please do contact me if you have any additional q...

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Thank you for contacting us yesterday in regards to the Anti-Nicastrin antibody (ab45425) and Anti-PEN2 antibody (ab109619).

As discussed over the phone, I have requested further information regarding the immunogen used to raise the two antib...

Read More