Major sites of expression of PEP Carboxylase are liver, kidney and adipocytes. PEP carboxylase, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein has also been characterized.
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