Overview

  • Product name
  • Description
    Rabbit polyclonal to PEPD
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Human PEPD.
    Database link: P12955

  • Positive control
    • BT474, 293T, SH-SYSY and M21 extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab186851 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 55 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function
    Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
  • Involvement in disease
    Defects in PEPD are a cause of prolidase deficiency (PD) [MIM:170100]. Prolidase deficiency is an autosomal recessive disorder associated with iminodipeptiduria. The clinical phenotype includes skin ulcers, mental retardation, recurrent infections, and a characteristic facies. These features, however are incompletely penetrant and highly variable in both age of onset and severity. There is a tight linkage between the polymorphisms of prolidase and the myotonic dystrophy trait.
  • Sequence similarities
    Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.
  • Information by UniProt
  • Database links
  • Alternative names
    • Aminoacyl L proline hydrolase antibody
    • Imidodipeptidase antibody
    • MGC10905 antibody
    • MGC95081 antibody
    • Pep 4 antibody
    • Pep4 antibody
    • pepD antibody
    • PEPD_HUMAN antibody
    • Peptidase 4 antibody
    • Peptidase D antibody
    • Prolidase antibody
    • Proline dipeptidase antibody
    • X pro dipeptidase antibody
    • X-Pro dipeptidase antibody
    • Xaa-Pro dipeptidase antibody
    see all

Images

  • All lanes : Anti-PEPD antibody (ab186851) at 1/500 dilution

    Lane 1 : BT474 cell extract
    Lane 2 : A549 cell extract
    Lane 3 : 293T cell extract
    Lane 4 : SH-SY5Y cell extract
    Lane 5 : M21 cell extract


    Predicted band size : 55 kDa

References

ab186851 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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