Overview

  • Product nameAnti-PER2 antibody
    See all PER2 primary antibodies
  • Description
    Goat polyclonal to PER2
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-DQQPKAPLTRDE

    with a Cysteine residue linker, corresponding to amino acids 1029-1040 of Human PER2 (NP_073728.1).

  • Positive control
    • Human heart and placenta tissues.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab118489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

Target

  • FunctionComponent of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK
    NPAS2-BMAL1
    BMAL2-induced transactivation.
  • Tissue specificityWidely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low level in lung.
  • Involvement in diseaseDefects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • Sequence similaritiesContains 1 PAC (PAS-associated C-terminal) domain.
    Contains 2 PAS (PER-ARNT-SIM) domains.
  • Post-translational
    modifications
    Phosphorylated by CSNK1E and CSNK1D. Phosphorylation results in PER2 protein degradation.
  • Cellular localizationNucleus. Cytoplasm. Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.
  • Information by UniProt
  • Database links
  • Alternative names
    • Circadian clock protein PERIOD 2 antibody
    • FASPS antibody
    • FASPS1 antibody
    • hPER 2 antibody
    • hPER2 antibody
    • KIAA0347 antibody
    • OTTHUMP00000164476 antibody
    • PER 2 antibody
    • PER2 antibody
    • PER2_HUMAN antibody
    • Period 2 antibody
    • Period 2 isoform 1 antibody
    • Period circadian clock 2 antibody
    • Period circadian protein 2 antibody
    • Period circadian protein homolog 2 antibody
    • Period homolog 2 (Drosophila) antibody
    • Period homolog 2 antibody
    • Period, Drosophila, homolog of, 2 antibody
    • Period2 antibody
    see all

Anti-PER2 antibody images

  • ab118489 at 7.5µg/ml staining PER2 in Formalin-fixed, Paraffin-embedded Human heart tissue by Immunohistochemistry.
  • ab118489 at 7.5µg/ml staining PER2 in Formalin-fixed, Paraffin-embedded Human placenta tissue by Immunohistochemistry.

References for Anti-PER2 antibody (ab118489)

ab118489 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"