Overview

  • Product nameAnti-Peroxiredoxin 1 antibody
    See all Peroxiredoxin 1 primary antibodies
  • Description
    Goat polyclonal to Peroxiredoxin 1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Cynomolgus Monkey, Chinese Hamster
  • Immunogen

    Synthetic peptide:

    C-SDPKRTIAQDYG

    , corresponding to internal sequence amino acids 106-117 of Human Peroxiredoxin 1 (NP_859048.1)

  • Positive control
    • IHC-P: placenta or thyroid tissue. WB: HepG2, HEK293 or A431 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab109766 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 23-24 kDa (predicted molecular weight: 22 kDa).
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • FunctionInvolved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
  • Sequence similaritiesBelongs to the ahpC/TSA family.
    Contains 1 thioredoxin domain.
  • Post-translational
    modifications
    Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.
  • Cellular localizationCytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links
  • Alternative names
    • Heme binding 23 kDa protein antibody
    • MSP23 antibody
    • Natural killer cell-enhancing factor A antibody
    • NKEF A antibody
    • NKEF-A antibody
    • NKEFA antibody
    • OSF3 antibody
    • Osteoblast specific factor 3 antibody
    • PAG antibody
    • Paga antibody
    • PAGB antibody
    • Peroxiredoxin-1 antibody
    • PRDX1 antibody
    • PRDX1_HUMAN antibody
    • Proliferation associated gene A antibody
    • Proliferation-associated gene protein antibody
    • PRX1 antibody
    • PrxI antibody
    • TDPX2 antibody
    • Thioredoxin peroxidase 2 antibody
    • Thioredoxin-dependent peroxide reductase 2 antibody
    see all

Anti-Peroxiredoxin 1 antibody images

  • Anti-Peroxiredoxin 1 antibody (ab109766) at 0.01 µg/ml (incubation time: 1 hour) + HepG2 lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 22 kDa
  • ab109766 at 2.5µg/ml staining Peroxiredoxin 1 in formalin-fixed, paraffin-embedded Human placenta tissue.
  • ab109766 at 2.5µg/ml staining Peroxiredoxin 1 in formalin-fixed, paraffin-embedded Human thyroid tissue.

References for Anti-Peroxiredoxin 1 antibody (ab109766)

ab109766 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"