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Overview
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Product nameAnti-PEX13 antibody
See all PEX13 primary antibodies -
DescriptionRabbit polyclonal to PEX13
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Host speciesRabbit
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Tested applicationsSuitable for: WB, IHC-Pmore details
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Species reactivityReacts with: Human
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Immunogen
Synthetic peptide within Human PEX13 aa 342-403. The exact sequence is proprietary. NP_002609.1
Sequence:TVESSKVSKQQQSFTNPTLTKGATVADSDEQEAAFESVFVETNKVPVAPD SIGKDGEKQDL
Database link: Q92968 -
Positive control
- Human tonsil tissue; MOLT4 cell lysate.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
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Storage bufferpH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 89% PBS, 10% Glycerol -
Concentration information loading... -
PurityImmunogen affinity purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Positive Controls
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Related Products
Applications
Our Abpromise guarantee covers the use of ab190213 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/500 - 1/3000. Predicted molecular weight: 44 kDa. | |
| IHC-P | Use a concentration of 10 µg/ml. |
Target
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FunctionComponent of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins.
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Involvement in diseaseDefects in PEX13 are the cause of peroxisome biogenesis disorder complementation group 13 (PBD-CG13) [MIM:601789]; also known as PBD-CGH. PBD-CG13 is a peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS).
Defects in PEX13 are a cause of adrenoleukodystrophy neonatal (NALD) [MIM:202370]. NALD is a peroxisome biogenesis disorder (PBD) characterized by the accumulation of very long-chain fatty acids, adrenal insufficiency and mental retardation. -
Sequence similaritiesBelongs to the peroxin-13 family.
Contains 1 SH3 domain. -
Cellular localizationPeroxisome membrane.
- Information by UniProt
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Database links
- Entrez Gene: 5194 Human
- Omim: 601789 Human
- SwissProt: Q92968 Human
- Unigene: 161377 Human
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Alternative names
- 2610008O20Rik antibody
- NALD antibody
- OTTMUSP00000005454 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PEX13 antibody (ab190213)Immunohistochemical analysis of formalin fixed, paraffin embedded Human tonsil tissue labeling PEX13 with ab190213 at 10 µg/ml.
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Western blot - Anti-PEX13 antibody (ab190213)Anti-PEX13 antibody (ab190213) at 1/1000 dilution + MOLT4 cell lysate at 30 µg
Predicted band size: 44 kDa7.5% SDS PAGE
References
ab190213 has not yet been referenced specifically in any publications.
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"