Overview

  • Product nameAnti-PEX7 antibody
    See all PEX7 primary antibodies
  • Description
    Rabbit polyclonal to PEX7
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 2-51 (SAVCGGAARM LRTPGRHGYA AEFSPYLPGR LACATAQHYG IAGCGTLLIL) of Human PEX7 (NP_000279).

  • Positive control
    • MCF7 cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab90822 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 36 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionBinds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.
  • Tissue specificityUbiquitous. Highest expression in pancreas, skeletal muscle and heart.
  • Involvement in diseaseDefects in PEX7 are the cause of peroxisome biogenesis disorder complementation group 11 (PBD-CG11) [MIM:614879]. PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum. The PBD group is genetically heterogeneous with at least 13 distinct genetic groups as concluded from complementation studies.
    Defects in PEX7 are the cause of rhizomelic chondrodysplasia punctata type 1 (RCDP1) [MIM:215100]. RCDP1 is characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation.
    Defects in PEX7 are the cause of peroxisome biogenesis disorder 9B (PBD9B) [MIM:614879]. A peroxisome biogenesis disorder with unusually mild clinical and biochemical manifestations. Affected individuals manifest a variable phenotype similar to, and in some cases indistinguishable from, classic Refsum disease. Variable features include ocular abnormalities, sensorimotor neuropathy, ichthyosis, deafness, chondrodysplasia punctata without rhizomelia or growth failure.
  • Sequence similaritiesBelongs to the WD repeat peroxin-7 family.
    Contains 6 WD repeats.
  • Cellular localizationPeroxisome. Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • PBD9B antibody
    • PCDP1 antibody
    • Peroxin 7 antibody
    • Peroxin-7 antibody
    • Peroxisomal PTS2 receptor antibody
    • Peroxisomal targeting signal 2 receptor antibody
    • Peroxisome biogenesis factor 7 antibody
    • Peroxisome targeting signal 2 receptor antibody
    • PEX7 antibody
    • PEX7 protein antibody
    • PEX7_HUMAN antibody
    • PTS2 receptor antibody
    • PTS2R antibody
    • RCDP1 antibody
    • RD antibody
    see all

Anti-PEX7 antibody images

  • Anti-PEX7 antibody (ab90822) at 1 µg/ml (in 5% skim milk / PBS buffer) + MCF7 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 36 kDa

References for Anti-PEX7 antibody (ab90822)

ab90822 has not yet been referenced specifically in any publications.

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