Overview

  • Product name
    PF 670462 (mM/ml)
  • Description
    Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. 1 ml water soluble pack.
  • Biological description

    Potent, selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM for CK1ε and CK1δ, respectively). Shows >300-fold selectivity over CK2 and selectivity over more than 40 other kinases. Alters circadian rhythms in vivo.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.

  • Purity
    > 99%

Properties

  • Chemical name
    4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride
  • Molecular weight
    410.32
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C19H20FN5.2HCl
  • CAS Number
    950912-80-8
  • PubChem identifier
    51049607
  • Storage instructions
    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in 1 ml water to give specified mM/ml concentration
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    Cl.Cl.Nc1nccc(n1)c3c(ncn3C2CCCCC2)c4ccc(F)cc4
  • Source

    Synthetic

  • Research areas

References

ab146728 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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