Potent and selective 6-phosphofructo-2-kinase (PFK) inhibitor (IC50 = 207 nM). Rapidly induces apoptosis in transformed cells. Suppresses glucose uptake and growth in cancer cells. Show antitumor effects in vivo.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in ethanol to 5 mM and in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Clem BF et al. Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol Cancer Ther12:1461-70 (2013).
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Mustroph A et al. Characterization of the phosphofructokinase gene family in rice and its expression under oxygen deficiency stress. Front Plant Sci4:125 (2013).
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Jia SS & Liu YH [Effects of estrogen on the expression of phosphofructokinase muscle-specific isoform in genioglossus of chronic intermittent hypoxia rats]. Zhonghua Kou Qiang Yi Xue Za Zhi45:627-30 (2010).
Read more (PubMed: 21176602) »