Overview

  • Product name
    PFK15
  • Description
    Potent, selective 6-phosphofructo-2-kinase (PFK) inhibitor
  • Biological description
    Potent and selective 6-phosphofructo-2-kinase (PFK) inhibitor (IC50 = 207 nM). Rapidly induces apoptosis in transformed cells. Suppresses glucose uptake and growth in cancer cells. Show antitumor effects in vivo.
  • Purity
    > 99%

Properties

  • Chemical name
    (E)-1-Pyridin-4-yl-3-quinolin-2-ylprop-2-en-1-one
  • Molecular weight
    260.29
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C17H12N2O
  • CAS Number
    4382-63-2
  • PubChem identifier
    25142799
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 5 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1=CC=C2C(=C1)C=CC(=N2)/C=C/C(=O)C3=CC=NC=C3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Clem BF  et al. Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol Cancer Ther 12:1461-70 (2013). Read more (PubMed: 23674815) »
  • Mustroph A  et al. Characterization of the phosphofructokinase gene family in rice and its expression under oxygen deficiency stress. Front Plant Sci 4:125 (2013). Read more (PubMed: 23717315) »
  • Jia SS & Liu YH [Effects of estrogen on the expression of phosphofructokinase muscle-specific isoform in genioglossus of chronic intermittent hypoxia rats]. Zhonghua Kou Qiang Yi Xue Za Zhi 45:627-30 (2010). Read more (PubMed: 21176602) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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