Overview

  • Product nameAnti-PFTK1 antibody
    See all PFTK1 primary antibodies
  • Description
    Mouse polyclonal to PFTK1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length PFTK1 protein (Human)

  • Positive control
    • PFTK1 transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab67997 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 53 kDa (predicted molecular weight: 53 kDa).

Target

  • FunctionSerine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
  • Tissue specificityHighly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Contains 1 protein kinase domain.
  • Cellular localizationCell membrane. Cytoplasm. Nucleus. Recruited to the cell membrane by CCNY.
  • Information by UniProt
  • Database links
  • Alternative names
    • cdk14 antibody
    • CDK14_HUMAN antibody
    • Cell division protein kinase 14 antibody
    • Cyclin-dependent kinase 14 antibody
    • hPFTAIRE1 antibody
    • KIAA0834 antibody
    • mKIAA0834 antibody
    • PFTAIRE protein kinase 1 antibody
    • PFTAIRE1 antibody
    • PFTK1 antibody
    • Serine/threonine protein kinase PFTAIRE 1 antibody
    • Serine/threonine-protein kinase PFTAIRE-1 antibody
    see all

Anti-PFTK1 antibody images

  • All lanes : Anti-PFTK1 antibody (ab67997) at 1/500 dilution

    Lane 1 : PFTK1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 53 kDa
    Observed band size : 53 kDa

References for Anti-PFTK1 antibody (ab67997)

ab67997 has not yet been referenced specifically in any publications.

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