Overview

  • Product nameAnti-PGC1 beta antibody
    See all PGC1 beta primary antibodies
  • Description
    Goat polyclonal to PGC1 beta
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Rhesus monkey, Marmoset (common)
  • Immunogen

    Synthetic peptide: AGNDCGALLDEELS, corresponding to amino acids 2-15 of Human PGC1 beta (NP_573570.3).

  • Positive control
    • Human Heart, Human Spleen
  • General notes

    This product may be covered by one or more of the following U.S. Patents.

    6,166,192
    6,426,411
    6,525,178
    6,872,391
    6,908,987
    7,250,283
    7,091,006
    7,354,738
    8,105,774
    8,445,233

     

Associated products

Applications

Our Abpromise guarantee covers the use of ab118603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3.75 - 7.5 µg/ml.

Target

  • FunctionPlays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
  • Tissue specificityUbiquitous with higher expression in heart, brain and skeletal muscle.
  • Sequence similaritiesContains 1 RRM (RNA recognition motif) domain.
  • DomainContains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • PERC antibody
    • peroxisome proliferative activated receptor, gamma, coactivator 1, antibody
    • peroxisome proliferator-activated receptor gamma coactivator 1 beta antibody
    • Peroxisome proliferator-activated receptor gamma coactivator 1-beta antibody
    • peroxisome proliferator-activated receptor gamma, coactivator 1 beta antibody
    • PGC-1(beta) antibody
    • PGC-1-beta antibody
    • PGC-1-related estrogen receptor alpha coactivator antibody
    • PGC1 antibody
    • PPAR gamma coactivator-1beta antibody
    • PPAR-gamma coactivator 1-beta antibody
    • PPARGC-1-beta antibody
    • PPARGC1 antibody
    • Ppargc1b antibody
    • PRGC2_HUMAN antibody
    see all

Anti-PGC1 beta antibody images

  • ab118603 at 3.75 µg/ml staining PGC1 beta in Human Heart by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
  • ab118603 at 3.75 &microg/ml staining PGC1 beta in Human Skeletal Muscle by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

References for Anti-PGC1 beta antibody (ab118603)

ab118603 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab118603.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"