Overview

  • Product name
  • Description
    Goat polyclonal to PGRPS
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog
  • Immunogen

    Synthetic peptide:

    C-PGNQLYHLIQN

    , corresponding to C terminal amino acids 179-189 of human PGRPS (NP_005082.1).

  • Positive control
    • Jurkat cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab82163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 22 kDa.
IHC-P Use a concentration of 3 - 6 µg/ml.

Target

  • Function
    Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
  • Tissue specificity
    Highly expressed in bone marrow. Weak expression found in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils.
  • Sequence similarities
    Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
  • Post-translational
    modifications
    N-glycosylated. N-glycosylation is required for bactericidal activity.
  • Cellular localization
    Secreted. Cytoplasmic granule.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC126894 antibody
    • MGC126896 antibody
    • Peptidoglycan recognition protein 1 antibody
    • Peptidoglycan recognition protein antibody
    • Peptidoglycan recognition protein short antibody
    • PGLYRP antibody
    • PGLYRP1 antibody
    • PGRP antibody
    • PGRP S antibody
    • PGRP-S antibody
    • PGRP1_HUMAN antibody
    • PHRP, short antibody
    • SBBI68 antibody
    • TAG7 antibody
    • TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein) antibody
    • TNFSF 3L antibody
    • TNFSF3L antibody
    • UNQ639/PRO1269 antibody
    see all

Images

  • Anti-PGRPS antibody (ab82163) at 0.3 µg/ml + Jurkat cell lysate at 35 µg

    Predicted band size : 22 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)
  • ab82163 at 3.8 µg/ml staining PGRPS in Human spleen by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

References

ab82163 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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