The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesStable for one year.
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated APRIL (for a proliferation-inducing ligand), TALL-2 (for TNF- and ApoL-related Leukocyte-expressed Ligand 2), and TRDL 1a (for TNF related death ligand 1a) in human and mouse. Two receptors for APRIL were recently identified and designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its close relative BlyS and their receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Acidic (leucine rich) nuclear phosphoprotein 32 family member B
Acidic leucine rich nuclear phosphoprotein 32 family member B
Acidic leucine-rich nuclear phosphoprotein 32 family member B
Acidic nuclear phosphoprotein 32 family member B
Acidic protein rich in leucines
Proliferation related acidic leucine rich protein
Putative HLA-DR-associated protein I-2
Silver stainable protein SSP 29
Silver stainable protein SSP29
Silver-stainable protein SSP29
FunctionMultifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
Tissue specificityExpressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.
Sequence similaritiesBelongs to the ANP32 family. Contains 4 LRR (leucine-rich) repeats. Contains 1 LRRCT domain.
DomainHistone binding is mediated by the concave surface of the LRR region.
Post-translational modificationsSome glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group.
Cellular localizationNucleus. Accumulates in the nuclei at the S phase and Cytoplasm. Lacks a nuclear localization signal.