• Product nameAnti-PHAX antibody
  • Description
    Rabbit polyclonal to PHAX
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from an internal region of Human PHAX.

  • Positive control
    • HT-29 cell lysate


Associated products


Our Abpromise guarantee covers the use of ab110525 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 44 kDa.


  • FunctionA phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
  • Sequence similaritiesBelongs to the PHAX family.
  • Post-translational
    Phosphorylated in the nucleus. Dephosphorylated in the cytoplasm (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus > nucleoplasm. Nucleus > Cajal body. Cytoplasm. Located in the nucleoplasm and Cajal bodies. Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies.
  • Information by UniProt
  • Database links
  • Alternative names
    • PHAX antibody
    • PHAX_HUMAN antibody
    • Phosphorylated adapter RNA export protein antibody
    • RNA U small nuclear RNA export adapter protein antibody
    • RNUXA antibody
    see all

Anti-PHAX antibody images

  • All lanes : Anti-PHAX antibody (ab110525) at 1/500 dilution

    Lane 1 : HT-29 cell lysate
    Lane 2 : HT-29 cell lysate with blocking peptide at 10 µg

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 44 kDa

References for Anti-PHAX antibody (ab110525)

ab110525 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab110525.
Please use the links above to contact us or submit feedback about this product.