Anti-PHD finger protein 6 antibody (ab84537)

Overview

  • Product name
    Anti-PHD finger protein 6 antibody
    See all PHD finger protein 6 primary antibodies
  • Description
    Rabbit polyclonal to PHD finger protein 6
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rabbit, Horse, Cow, Dog, Pig, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Chinese hamster, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within residue 125 - 175 of Human PHD finger protein 6 (NP_115834.1)

  • Positive control
    • Human: anaplastic thyroid carcinoma, breast carcinoma, Hodgkin's lymphoma, ovarian carcinoma, prostate carcinoma. Mouse: renal cell carcinoma.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab84537 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer may enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      May play a role in transcriptional regulation.
    • Tissue specificity
      Ubiquitously expressed.
    • Involvement in disease
      Defects in PHF6 are the cause of Boerjeson-Forssman-Lehmann syndrome (BFLS) [MIM:301900]; also known as Boerjeson-Forssman syndrome (BORJ). BFLS is a X-linked recessive disorder characterized by moderate to severe mental retardation, epilepsy, hypogonadism, hypometabolism, obesity with marked gynecomastia, swelling of subcutaneous tissue of the face, narrow palpebral fissure and large but not deformed ears.
    • Sequence similarities
      Contains 2 PHD-type zinc fingers.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization
      Nucleus. Nucleus > nucleolus. Nuclear, it particularly localizes to the nucleolus.
    • Information by UniProt
    • Database links
    • Alternative names
      • AC004383.6 antibody
      • BFLS antibody
      • BORJ antibody
      • CENP 31 antibody
      • Centromere protein 31 antibody
      • MGC14797 antibody
      • OTTHUMP00000024063 antibody
      • PHD finger protein 6 antibody
      • PHD like zinc finger protein antibody
      • PHD-like zinc finger protein antibody
      • Phf6 antibody
      • PHF6_HUMAN antibody
      see all

    Images

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human breast carcinoma, using 1/250 ab84537 followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse renal cell carcinoma, using 1/250 ab84537 followed by DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Humanskin carcinoma, using 1/250 ab84537in conjunction with 1/100 Goat anti-Rabbit IgG conjugated with Hilyte PlusTM 555 (red).

    References

    ab84537 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab84537.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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