Overview

  • Product name
  • Description
    Rabbit polyclonal to Phex
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant protein fragment corresponding to a region within amino acids 1 and 325 of Human Phex.

  • Positive control
    • Molt-4 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab96072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 86 kDa.

Target

  • Function
    Probably involved in bone and dentin mineralization and renal phosphate reabsorption.
  • Tissue specificity
    Lymphocytes and fetal brain; not in adult brain, placenta, skeletal muscle and pancreas; not in adult and fetal heart, lung, liver and kidney.
  • Involvement in disease
    Defects in PHEX are a cause of X-linked hypophosphatemic rickets (HYP) [MIM:307800]. HYP is an X-linked dominant disorder characterized by impaired phosphate uptake in the kidney, which is likely to be caused by abnormal regulation of sodium phosphate cotransport in the proximal tubules. Clinical manifestations include skeletal deformities, growth failure, craniosynostosis, paravertebral calcifications, pseudofractures in lower extremities, and muscular hypotonia with onset in early childhood. X-linked hypophosphatemic rickets is the most common form of hypophosphatemia with an incidence of 1 in 20000.
  • Sequence similarities
    Belongs to the peptidase M13 family.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • HPDR antibody
    • HPDR1 antibody
    • HYP antibody
    • HYP1 antibody
    • LXHR antibody
    • Metalloendopeptidase homolog PEX antibody
    • PEX antibody
    • Phex antibody
    • PHEX_HUMAN antibody
    • Phosphate regulating endopeptidase homolog X linked antibody
    • Phosphate regulating gene with homologies to endopeptidases on the X chromosome antibody
    • Phosphate-regulating neutral endopeptidase antibody
    • Vitamin D-resistant hypophosphatemic rickets protein antibody
    • X-linked hypophosphatemia protein antibody
    • XLH antibody
    see all

Images

  • Anti-Phex antibody (ab96072) at 1/1000 dilution + Molt-4 cell lysate at 30 µg

    Predicted band size : 86 kDa

References

ab96072 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab96072.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up