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Product name
Phorbol 12-myristate 13-acetate (PMA)
Description
PKC activator
Alternative names
- PMA
Biological description
Potent nanomolar activator of protein kinase C in vivo and in vitro. Binds to C1 domain of protein kinase C, induces membrane translocation and enzyme activation. Also reported to have actions on non kinase proteins including chimaerins, RasGRP and Unc-13/Munc-13. Extremely potent mouse skin tumor promoter.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
Phorbol 12-myristate 13-acetate
Molecular Weight
616.83
Chemical structure
Molecular formula
C36H56O8
CAS Number
16561-29-8
Solubility
Soluble in DMSO to 100 mM and in ethanol to 10 mM
PubChem identifier
0
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Protein Kinase C >> Activators
Biochemicals >> Chemical Type >> Biochemicals
References for Phorbol 12-myristate 13-acetate (PMA) (ab120297)
This product has been referenced in:
- Kazanietz MG Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters. Mol Carcinog 28:5-11 (2000).Read more (PubMed: 10820483) »
- Kazanietz MG et al. Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties. Biochem Pharmacol 60:1417-24 (2000).Read more (PubMed: 11020443) »
See all 3 publications for this product
Publishing research using ab120297? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"