Anti-Phosphoserine Aminotransferase antibody (ab67367)

Overview

  • Product nameAnti-Phosphoserine Aminotransferase antibody
    See all Phosphoserine Aminotransferase primary antibodies
  • Description
    Mouse polyclonal to Phosphoserine Aminotransferase
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Phosphoserine Aminotransferase protein (Human)

  • Positive control
    • Phosphoserine Aminotransferase transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab67367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 37 kDa (predicted molecular weight: 40 kDa).

Target

  • FunctionCatalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
  • Tissue specificityExpressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon.
  • PathwayAmino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.
    Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.
  • Involvement in diseaseDefects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD) [MIM:610992]. PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.
  • Sequence similaritiesBelongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 2.6.1.52 antibody
    • Endometrial progesterone induced protein antibody
    • EPIP antibody
    • MGC1460 antibody
    • NLS2 antibody
    • Phosphohydroxythreonine aminotransferase antibody
    • phosphoserine aminotransferase 1 antibody
    • Phosphoserine aminotransferase antibody
    • PSA antibody
    • PSAT antibody
    • Psat1 antibody
    • PSATD antibody
    • SERC_HUMAN antibody
    see all

Anti-Phosphoserine Aminotransferase antibody images

  • All lanes : Anti-Phosphoserine Aminotransferase antibody (ab67367) at 1/500 dilution

    Lane 1 : Phosphoserine Aminotransferase transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution

    Predicted band size : 40 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)

References for Anti-Phosphoserine Aminotransferase antibody (ab67367)

ab67367 has not yet been referenced specifically in any publications.

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