Overview

  • Product nameAnti-Phosphoserine Aminotransferase antibody
    See all Phosphoserine Aminotransferase primary antibodies
  • Description
    Rabbit polyclonal to Phosphoserine Aminotransferase
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cow
  • Immunogen

    Recombinant protein fragment with a sequence corresponding to a region within amino acids 48 and 298 of Human Phosphoserine Aminotransferase (NP_478059).

  • Positive control
    • 293T, A431, H1299, HeLa, HepG2, Molt-4 and Raji cell lines. H1299 whole cell lysate for WB and A549 cells for IF.

Properties

Applications

Our Abpromise guarantee covers the use of ab96136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 40 kDa.
ICC/IF 1/100 - 1/200.

Target

  • FunctionCatalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
  • Tissue specificityExpressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon.
  • PathwayAmino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.
    Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.
  • Involvement in diseaseDefects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD) [MIM:610992]. PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.
  • Sequence similaritiesBelongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 2.6.1.52 antibody
    • Endometrial progesterone induced protein antibody
    • EPIP antibody
    • MGC1460 antibody
    • NLS2 antibody
    • Phosphohydroxythreonine aminotransferase antibody
    • phosphoserine aminotransferase 1 antibody
    • Phosphoserine aminotransferase antibody
    • PSA antibody
    • PSAT antibody
    • Psat1 antibody
    • PSATD antibody
    • SERC_HUMAN antibody
    see all

Anti-Phosphoserine Aminotransferase antibody images

  • Anti-Phosphoserine Aminotransferase antibody (ab96136) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

    Predicted band size : 40 kDa
  • ab96136, at 1/200 staining paraformaldehyde-fixed A549 cells by Immunofluorescence (Panel 1) and merged with DNA probe (Panel 2).

References for Anti-Phosphoserine Aminotransferase antibody (ab96136)

This product has been referenced in:
  • Kim SK  et al. Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes. PLoS One 9:e101004 (2014). WB ; Human . Read more (PubMed: 24979213) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"