Anti-Phosphoserine phosphatase antibody [3G12] (ab48512)

Overview

  • Product name
    Anti-Phosphoserine phosphatase antibody [3G12]
    See all Phosphoserine phosphatase primary antibodies
  • Description
    Mouse monoclonal [3G12] to Phosphoserine phosphatase
  • Specificity
    This antibody is specific for D- and L- phosphoserine
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 1-225 of Human Phosphoserine phosphatase, purified from E. coli

  • Positive control
    • Cell lysates of Mouse brain

Properties

Applications

Our Abpromise guarantee covers the use of ab48512 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB 1/1000 - 1/2000. Detects a band of approximately 26 kDa (predicted molecular weight: 25 kDa).

Target

  • Function
    Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.
  • Pathway
    Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.
  • Involvement in disease
    Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.
  • Sequence similarities
    Belongs to the SerB family.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 3.1.3.3 antibody
    • L 3 phosphoserine phosphatase antibody
    • L-3-phosphoserine phosphatase antibody
    • O phosphoserine phosphohydrolase antibody
    • O-phosphoserine phosphohydrolase antibody
    • Phosphoserine phosphatase antibody
    • Phosphoserine phosphatase deficiency, included antibody
    • PSP antibody
    • PSPase antibody
    • Psph antibody
    • PSPHD antibody
    • SERB_HUMAN antibody
    see all

Images

  • Anti-Phosphoserine phosphatase antibody [3G12] (ab48512) at 1/1000 dilution + Cell lysates of Mouse brain (30µg)

    Secondary
    goat anti-mouse secondary antibody conjugated to HRP
    Developed using the ECL technique

    Predicted band size : 25 kDa
    Observed band size : 26 kDa (why is the actual band size different from the predicted?)

References

ab48512 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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