Overview

  • Product nameAnti-PHYH antibody
    See all PHYH primary antibodies
  • Description
    Rabbit polyclonal to PHYH
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 34-321 of Human PHYH (BC029512).

  • Positive control
    • Human fetal kidney and liver lysates; Human breast carcinoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab118195 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 39 kDa.
IHC-P 1/100 - 1/500.

Target

  • FunctionConverts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.
  • Tissue specificityExpressed in liver, kidney, and T-cells, but not in spleen, brain, heart, lung and skeletal muscle.
  • PathwayLipid metabolism; fatty acid metabolism.
  • Involvement in diseaseDefects in PHYH are a cause of Refsum disease (RD) [MIM:266500]. RD is an autosomal recessive disorder characterized clinically by a tetrad of abnormalities: retinitis pigmentosa, peripheral neuropathy, cerebellar ataxia, and elevated protein levels in the cerebrospinal fluid (CSF). Patients exhibit accumulation of the branched-chain fatty acid, phytanic acid, in blood and tissues. Less constant features are nerve deafness, anosmia, skeletal abnormalities, ichthyosis, cataracts and cardiac impairment. Manifestations of the disease appear in the second or third decade of life.
  • Sequence similaritiesBelongs to the PhyH family.
  • Cellular localizationPeroxisome.
  • Information by UniProt
  • Database links
  • Alternative names
    • LN1 antibody
    • LNAP1 antibody
    • LNAP1, mouse, homolog of antibody
    • OTTHUMP00000019131 antibody
    • OTTHUMP00000019132 antibody
    • OTTHUMP00000179083 antibody
    • OTTHUMP00000216226 antibody
    • PAHX antibody
    • PAHX_HUMAN antibody
    • peroxisomal antibody
    • PhyH antibody
    • PHYH1 antibody
    • Phytanic acid oxidase antibody
    • phytanoil-CoA alpha hydroxylase antibody
    • phytanoyl CoA 2 hydroxylase antibody
    • Phytanoyl CoA 2 oxoglutarate dioxygenase antibody
    • Phytanoyl CoA alpha hydroxylase antibody
    • Phytanoyl CoA dioxygenase antibody
    • Phytanoyl CoA dioxygenase peroxisomal antibody
    • Phytanoyl-CoA alpha-hydroxylase antibody
    • Phytanoyl-CoA dioxygenase antibody
    • RD antibody
    see all

Anti-PHYH antibody images

  • All lanes : Anti-PHYH antibody (ab118195) at 1/500 dilution

    Lane 1 : Human fetal kidney lysate
    Lane 2 : Human fetal liver lysate


    Predicted band size : 39 kDa
  • ab118195, at 1/100 dilution, staining PHYH in formalin-fixed, paraffin-embedded Human breast carcinoma tissue showing cytoplasmic staining, by Immunohistochemistry.

References for Anti-PHYH antibody (ab118195)

ab118195 has not yet been referenced specifically in any publications.

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