Anti-PI 3 Kinase p85 alpha antibody, prediluted (ab82159)

Overview

  • Product name
    Anti-PI 3 Kinase p85 alpha antibody, prediluted
    See all PI 3 Kinase p85 alpha primary antibodies
  • Description
    Rabbit polyclonal to PI 3 Kinase p85 alpha, prediluted
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to N terminus of human PI 3 Kinase p85 alpha.

  • Positive control
    • Human Placenta

Properties

Applications

Our Abpromise guarantee covers the use of ab82159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: Ready to use. Pretreatment: Boil tissue section in 10mM Citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
    • Tissue specificity
      Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
    • Sequence similarities
      Belongs to the PI3K p85 subunit family.
      Contains 1 Rho-GAP domain.
      Contains 2 SH2 domains.
      Contains 1 SH3 domain.
    • Domain
      The SH3 domain mediates the binding to CBLB, and to HIV-1 Nef.
    • Post-translational
      modifications
      Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
      Phosphorylated. Dephosphorylated by PTPRJ.
    • Information by UniProt
    • Database links
    • Alternative names
      • GRB1 antibody
      • p85 alpha antibody
      • p85 antibody
      • P85A_HUMAN antibody
      • Phosphatidylinositol 3 kinase associated p 85 alpha antibody
      • Phosphatidylinositol 3 kinase regulatory 1 antibody
      • Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 1 (p85 alpha) antibody
      • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha antibody
      • Phosphatidylinositol 3-kinase regulatory subunit alpha antibody
      • Phosphoinositide 3 kinase, regulatory subunit 1 (alpha) antibody
      • PI3 kinase p85 subunit alpha antibody
      • PI3-kinase regulatory subunit alpha antibody
      • PI3-kinase subunit p85-alpha antibody
      • PI3K antibody
      • PI3K regulatory subunit alpha antibody
      • Pik3r1 antibody
      • PtdIns 3 kinase p85 alpha antibody
      • PtdIns-3-kinase regulatory subunit alpha antibody
      • PtdIns-3-kinase regulatory subunit p85-alpha antibody
      see all

    Images

    • Human placenta stained with ab82159

    References

    ab82159 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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