Overview

  • Product name
  • Description
    Rabbit polyclonal to PICK1
  • Specificity
    Recognizes PICK1.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    6xhis tagged fusion protein:

    EKMELLDQKH VQDIVFQLQR FVSTMSKYYN DCYAVLQDAD VFPIEVDLAH TTLAYGPNQG SFTDGEEEDE EEEDGAAREV SKDACGATGP TDKGGSWCDS

    , corresponding to C terminal amino acids 317-416 of Mouse PICK1.

  • Positive control
    • RIPA lysates from rat brain microsomal preparation.

Properties

Applications

Our Abpromise guarantee covers the use of ab15001 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 50 kDa.

Target

  • Function
    Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 1 AH domain.
    Contains 1 PDZ (DHR) domain.
  • Post-translational
    modifications
    Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
  • Cellular localization
    Cytoplasm > perinuclear region. Cell junction > synapse. Also present at excitatory synapses.
  • Information by UniProt
  • Database links
  • Alternative names
    • dJ1039K5 antibody
    • MGC15204 antibody
    • OTTHUMP00000028509 antibody
    • PICK 1 antibody
    • Pick1 antibody
    • PICK1_HUMAN antibody
    • PRKCA binding protein antibody
    • PRKCA-binding protein antibody
    • PRKCABP antibody
    • Protein interacting with C kinase 1 antibody
    • Protein interacting with PRKCA antibody
    • Protein interacting with PRKCA 1 antibody
    • Protein kinase C alpha binding protein antibody
    • Protein kinase C-alpha-binding protein antibody
    • Protein that interacts with C kinase 1 antibody
    see all

References

ab15001 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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