Recombinant
RabMAb

Anti-PICK1 antibody [EPR4129(2)] (ab109249)

Overview

  • Product name
    Anti-PICK1 antibody [EPR4129(2)]
    See all PICK1 primary antibodies
  • Description
    Rabbit monoclonal [EPR4129(2)] to PICK1
  • Tested applications
    Suitable for: WB, IP, Flow Cytmore details
    Unsuitable for: ICC or IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to a region within the N terminus of Human PICK1.

  • Positive control
    • Fetal brain, HeLa, LnCaP and SH-SY5Y cell lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab109249 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 50 kDa (predicted molecular weight: 47 kDa).
IP 1/10 - 1/100.
Flow Cyt 1/10 - 1/100. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • Application notes
    Is unsuitable for ICC or IHC-P.
  • Target

    • Function
      Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
    • Tissue specificity
      Ubiquitous.
    • Sequence similarities
      Contains 1 AH domain.
      Contains 1 PDZ (DHR) domain.
    • Post-translational
      modifications
      Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
    • Cellular localization
      Cytoplasm > perinuclear region. Cell junction > synapse. Also present at excitatory synapses.
    • Information by UniProt
    • Database links
    • Alternative names
      • dJ1039K5 antibody
      • MGC15204 antibody
      • OTTHUMP00000028509 antibody
      • PICK 1 antibody
      • Pick1 antibody
      • PICK1_HUMAN antibody
      • PRKCA binding protein antibody
      • PRKCA-binding protein antibody
      • PRKCABP antibody
      • Protein interacting with C kinase 1 antibody
      • Protein interacting with PRKCA antibody
      • Protein interacting with PRKCA 1 antibody
      • Protein kinase C alpha binding protein antibody
      • Protein kinase C-alpha-binding protein antibody
      • Protein that interacts with C kinase 1 antibody
      see all

    Images

    • All lanes : Anti-PICK1 antibody [EPR4129(2)] (ab109249) at 1/1000 dilution

      Lane 1 : Fetal brain tissue lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : LnCaP cell lysate
      Lane 4 : SH SY5Y cell lysate


      Predicted band size : 47 kDa
      Observed band size : 50 kDa (why is the actual band size different from the predicted?)

    References

    ab109249 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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