Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab4964 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse PICK 1, catalog ab3420. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • dJ1039K5
    • MGC15204
    • OTTHUMP00000028509
    • PICK 1
    • Pick1
    • PICK1_HUMAN
    • PRKCA binding protein
    • PRKCA-binding protein
    • PRKCABP
    • Protein interacting with C kinase 1
    • Protein interacting with PRKCA
    • Protein interacting with PRKCA 1
    • Protein kinase C alpha binding protein
    • Protein kinase C-alpha-binding protein
    • Protein that interacts with C kinase 1
    see all
  • FunctionProbable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel.
  • Tissue specificityUbiquitous.
  • Sequence similaritiesContains 1 AH domain.
    Contains 1 PDZ (DHR) domain.
  • Post-translational
    modifications
    Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors.
  • Cellular localizationCytoplasm > perinuclear region. Cell junction > synapse. Also present at excitatory synapses.
  • Information by UniProt

References for PICK1 peptide (ab4964)

ab4964 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab4964.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"