Anti-PICP antibody [8] (ab17202)
Key features and details
- Mouse monoclonal [8] to PICP
- Suitable for: ELISA, IP, Sandwich ELISA
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-PICP antibody [8]
See all PICP primary antibodies -
Description
Mouse monoclonal [8] to PICP -
Host species
Mouse -
Specificity
ab17202 is specific for native PICP from amniotic fluid. -
Tested applications
Suitable for: ELISA, IP, Sandwich ELISAmore details -
Species reactivity
Reacts with: Human -
Immunogen
PICP purified from second trimester amniotic fluid by affinity chromatography.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 2.9% Sodium chloride -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
8 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab17202 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ELISA |
Use at an assay dependent concentration.
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IP |
Use at an assay dependent concentration.
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|
Sandwich ELISA |
Use at an assay dependent concentration.
Use as Capture antibody with recommended pair. |
Notes |
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ELISA
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
Sandwich ELISA
Use at an assay dependent concentration. Use as Capture antibody with recommended pair. |
Target
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Function
Type I collagen is a member of group I collagen (fibrillar forming collagen). -
Tissue specificity
Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite. -
Involvement in disease
Caffey disease
Ehlers-Danlos syndrome 1
Ehlers-Danlos syndrome 7A
Osteogenesis imperfecta 1
Osteogenesis imperfecta 2
Osteogenesis imperfecta 3
Osteogenesis imperfecta 4
Osteoporosis
A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGF. -
Sequence similarities
Belongs to the fibrillar collagen family.
Contains 1 fibrillar collagen NC1 domain.
Contains 1 VWFC domain. -
Domain
The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function. -
Post-translational
modificationsProline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains.
O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group. -
Cellular localization
Secreted > extracellular space > extracellular matrix. - Information by UniProt
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Database links
- Entrez Gene: 1277 Human
- Omim: 120150 Human
- SwissProt: P02452 Human
- Unigene: 172928 Human
- Unigene: 681002 Human
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Alternative names
- COL1A1 antibody
- Alpha 1 type I collagen antibody
- Alpha-1 type I collagen antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab17202 has not yet been referenced specifically in any publications.