Overview

  • Product namePifithrin-α-HBr
  • Description
    p53 Inhibitor
  • Biological descriptionp53 Inhibitor. Specifically blocks tumor supressor p53 transcriptional activity and can supress heat shock and glucocorticoid signalling pathways. Additionally offers protection to cells from p53 mediated apoptosis. Active in vivo; protects mice from chemotherapy side effects associated with p53 induction. Also aryl hydrocarbon receptor (AHR) agonist.
  • Purity> 98%
  • General notes

    Pifithrin-?-HBr is light senstive and it is recommended that the compound is protected from light.

Properties

    References for Pifithrin-α-HBr (ab120478)

    This product has been referenced in:
    • Sohn D  et al. Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell Death Differ 16:869-78 (2009). Read more (PubMed: 19229248) »
    • Hoagland MS  et al. The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor. J Pharmacol Exp Ther 314:603-10 (2005). Read more (PubMed: 15843497) »
    • Komarova EA  et al. p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways. J Biol Chem 278:15465-8 (2003). Read more (PubMed: 12637507) »
    • Komarov PG  et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285:1733-7 (1999). Read more (PubMed: 10481009) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"