Overview

  • Product name
  • Description
    Rabbit polyclonal to PIGA
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment corresponding to a region within amino acids 270-484 of Human PIGA (UniProt ID: P37287).

  • Positive control
    • NIH 3T3 whole cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 0.75% Glycine, 1.21% Tris, 10% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab154603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 54 kDa.

Target

  • Function
    Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
  • Pathway
    Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
  • Involvement in disease
    Paroxysmal nocturnal hemoglobinuria (PNH) [MIM:300818]: A disorder characterized by hemolytic anemia with hemoglobinuria, thromboses in large vessels, and a deficiency in hematopoiesis. Clinical manifestation of red blood cell breakdown with release of hemoglobin into the urine is manifested most prominently by dark-colored urine in the morning. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Multiple congenital anomalies-hypotonia-seizures syndrome 2 (MCAHS2) [MIM:300868]: An X-linked recessive developmental disorder characterized by dysmorphic features, neonatal hypotonia, myoclonic seizures, and variable congenital anomalies involving the central nervous, cardiac, and urinary systems. Most affected individuals die in infancy. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities
    Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Class A GlcNAc inositol phospholipid assembly protein antibody
    • GlcNAc PI synthesis protein antibody
    • GlcNAc-PI synthesis protein antibody
    • GPI3 antibody
    • MCAHS2 antibody
    • Phosphatidylinositol glycan anchor biosynthesis class A antibody
    • Phosphatidylinositol glycan biosynthesis class A protein antibody
    • Phosphatidylinositol N-acetylglucosaminyltransferase subunit A antibody
    • Phosphatidylinositol-glycan biosynthesis class A protein antibody
    • PIG A antibody
    • PIG-A antibody
    • Piga antibody
    • PIGA_HUMAN antibody
    see all

Images

  • Anti-PIGA antibody (ab154603) at 1/1000 dilution + NIH 3T3 whole cell lysate at 30 µg

    Predicted band size: 54 kDa



    10% SDS PAGE

References

ab154603 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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