Anti-PIK3R5 antibody - C-terminal (ab154043)

Overview

  • Product name
    Anti-PIK3R5 antibody - C-terminal
    See all PIK3R5 primary antibodies
  • Description
    Rabbit polyclonal to PIK3R5 - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Pig
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 603-880 of Human PIK3R5 (Uniprot ID: Q8WYR1).

  • Positive control
    • Human esophagus tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 0.75% Glycine, 1.21% Tris, 10% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab154043 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Regulatory subunit of the PI3K gamma complex.
  • Tissue specificity
    Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
  • Involvement in disease
    Note=Defects in PIK3R5 may be a cause of autosomal recessive ataxia with oculomotor apraxia (AOA). A PIK3R5 mutation segregates with the disease phenotype in a family affected by gait ataxia, cerebellar dysarthric speech, and impaired ocular movement. Additional features include reduced or absent tendon reflexes, severe cerebellar atrophy, marked vermal atrophy, moderately severe axonal sensory polyneuropathy with absent sensory nerve action potential in the lower extremities, and persistently elevated alpha-fetoprotein levels.
  • Domain
    The heterodimerization region allows the binding to the catalytic subunit.
  • Cellular localization
    Nucleus. Cytoplasm. Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5-bisphosphate 3-kinase regulatory subunit antibody
    • F730038I15Rik antibody
    • FOAP 2 antibody
    • FOAP2 antibody
    • OTTHUMP00000135339 antibody
    • p101 antibody
    • P101 PI3K antibody
    • p101-PI3K antibody
    • Phosphatidylinositol 4 antibody
    • Phosphatidylinositol 4,5 bisphosphate 3 kinase regulatory subunit antibody
    • Phosphoinositide 3 kinase, regulatory subunit 5 antibody
    • Phosphoinositide 3 kinase, regulatory subunit 5, p101 antibody
    • Phosphoinositide 3 kinase, regulatory subunit, polypeptide p101 antibody
    • Phosphoinositide 3-kinase regulatory subunit 5 antibody
    • PI3 kinase p101 subunit antibody
    • PI3 kinase regulatory subunit 5 antibody
    • PI3-kinase p101 subunit antibody
    • PI3-kinase regulatory subunit 5 antibody
    • PI3R5_HUMAN antibody
    • PIK3 R5 antibody
    • PIK3R5 antibody
    • Protein FOAP 2 antibody
    • Protein FOAP-2 antibody
    • PtdIns 3 kinase p101 antibody
    • PtdIns 3 kinase regulatory subunit antibody
    • PtdIns-3-kinase p101 antibody
    • PtdIns-3-kinase regulatory subunit antibody
    see all

Images

  • Immunohistochemical analysis of Formalin-fixed, Paraffin-embedded normal Human esophagus tissue labeling PIK3R5 with ab154043 at 1/100 dilution. Nuclei are counterstained with methyl green.

References

ab154043 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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