Overview

  • Product nameAnti-Pin1 antibody
    See all Pin1 primary antibodies
  • Description
    Rabbit polyclonal to Pin1
  • Tested applicationsSuitable for: ICC/IF, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthesized non-phosphopeptide derived from human Pin1 around the phosphorylation site of serine 1619 (R-M-SP-R-S).

  • Positive control
    • NIH/3T3 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab63623 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/500 - 1/1000.
ELISA 1/5000.
IHC-P 1/50 - 1/100.

Target

  • FunctionEssential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzing pSer/Thr-Pro cis/trans isomerizations.
  • Sequence similaritiesContains 1 PpiC domain.
    Contains 1 WW domain.
  • DomainThe WW domain is required for the interaction with STIL and KIF20B.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DOD antibody
    • DODO, Drosophila, homolog of antibody
    • FLJ40239 antibody
    • FLJ77628 antibody
    • MGC10717 antibody
    • NIMA interacting 1 antibody
    • Peptidyl prolyl cis trans isomerase NIMA interacting 1 antibody
    • Peptidyl prolyl cis/trans isomerase NIMA interacting antibody
    • Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody
    • Peptidyl-prolyl cis-trans isomerase pin1 antibody
    • Peptidylprolyl cis/trans isomerase NIMA interacting 1 antibody
    • Pin 1 antibody
    • Pin1 antibody
    • PIN1_HUMAN antibody
    • PPIase Pin1 antibody
    • Prolyl isomerase antibody
    • Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1 antibody
    • Protein NIMA interacting 1 antibody
    • Rotamase Pin1 antibody
    • UBL 5 antibody
    • UBL5 antibody
    see all

Anti-Pin1 antibody images

  • Immunofluorescence analysis of NIH/3T3 cells, using ab63623 at a dilution of 1/500-1/1000. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.
  • Immunohistochemical analysis of paraffin-embedded thyroid tissue, using ab63623. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.

References for Anti-Pin1 antibody (ab63623)

ab63623 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.  We do not currently have any additional IHC images available for ab63623.  As shown on our datasheet, we have validated this antibody using human thyroid tissue.  We will cover this antibody under our Abpromise guarantee f...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"