Overview

  • Product namePindolol
  • Description
    5-HT1A and 5-HT1B receptor antagonist
  • Biological description5-HT1A and 5-HT1B receptor antagonist (Ki and IC50 values are 8.9 and 6.8 nM at 5-HT1A and 5-HT1B receptors, respectively). Partial β3 adrenoceptor agonist (pEC50 = 5.11). Accelerates antidepressant effects of selective serotonin reuptake inhibitors (SSRIs).
  • Purity> 99%

Properties

    References for Pindolol (ab120521)

    This product has been referenced in:
    • Brahmadevara N  et al. Evidence against beta 3-adrenoceptors or low affinity state of beta 1-adrenoceptors mediating relaxation in rat isolated aorta. Br J Pharmacol 138:99-106 (2003). Read more (PubMed: 12522078) »
    • Artigas F  et al. How does pindolol improve antidepressant action? Trends Pharmacol Sci 22:224-8 (2001). Read more (PubMed: 11339972) »
    • Castro ME  et al. Affinity of (+/-)-pindolol, (-)-penbutolol, and (-)-tertatolol for pre- and postsynaptic serotonin 5-HT(1A) receptors in human and rat brain. J Neurochem 75:755-62 (2000). Read more (PubMed: 10899952) »
    • Maroteaux L  et al. Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A 89:3020-4 (1992). Read more (PubMed: 1557407) »

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