Overview

  • Product nameAnti-Pinin antibody
    See all Pinin primary antibodies
  • Description
    Rabbit polyclonal to Pinin
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 648-697 (RSVDRKRRDT SGLERSHKSS KGGSSRDTKG SKDKNSRSDR KRSISESSRS) of Human Pinin (NP_002678).

  • Positive control
    • 721_B cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab94610 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 82 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionTranscriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
  • Tissue specificityExpressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.
  • Sequence similaritiesBelongs to the pinin family.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus speckle. Cell junction > desmosome. Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
  • Information by UniProt
  • Database links
  • Alternative names
    • 140 kDa nuclear and cell adhesion-related phosphoprotein antibody
    • Desmosome-associated protein antibody
    • Domain-rich serine protein antibody
    • DRS antibody
    • DRS protein antibody
    • DRSP antibody
    • Melanoma metastasis clone A protein antibody
    • MEMA antibody
    • Nuclear protein SDK3 antibody
    • Pinin antibody
    • PININ_HUMAN antibody
    • PNN antibody
    • SR like protein antibody
    • SR-like protein antibody
    see all

Anti-Pinin antibody images

  • Anti-Pinin antibody (ab94610) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 82 kDa

References for Anti-Pinin antibody (ab94610)

ab94610 has not yet been referenced specifically in any publications.

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