Overview

  • Product namePioglitazone hydrochloride
  • Description
    Selective PPAR-γ agonist
  • Biological descriptionSelective PPAR-γ agonist (EC50 values are 280, >1000 and >1000 nM for PPAR isoforms γ, α and δ, respectively). Does not readily cross the blood-brain barrier. Antidiabetic activities in vivo, improves the response to circulating insulin.
  • Purity> 99%

Properties

    References for Pioglitazone hydrochloride (ab120794)

    This product has been referenced in:
    • Heneka MT  et al. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain 128:1442-53 (2005). Read more (PubMed: 15817521) »
    • Xu HE  et al. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A 98:13919-24 (2001). Read more (PubMed: 11698662) »
    • Colca JR  et al. Pioglitazone hydrochloride inhibits cholesterol absorption and lowers plasma cholesterol concentrations in cholesterol-fed rats. Diabetes 40:1669-74 (1991). Read more (PubMed: 1756906) »

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