Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SequenceGSSKKVTLSVLSRE-C
    • Amino acids2 to 15

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45602 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Pirin antibody (ab21202)

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

General Info

  • Alternative names
    • 3-dioxygenase PIR
    • Iron binding nuclear protein
    • Pir
    • PIR_HUMAN
    • Pirin
    • Probable quercetin 2
    • probable quercetin 2,3-dioxygenase PIR
    • Probable quercetinase
    see all
  • FunctionPossible transcriptional coregulator. May contribute to the regulation of cellular processes via its interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenase activity (in vitro).
  • Tissue specificityHighly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver.
  • PathwayFlavonoid metabolism; quercetin degradation.
  • Sequence similaritiesBelongs to the pirin family.
  • Cellular localizationNucleus. Cytoplasm. Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.
  • Information by UniProt

References for Pirin peptide (ab45602)

ab45602 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"