Overview

  • Product name
    Anti-PIRT antibody
  • Description
    Rabbit polyclonal to PIRT
  • Tested applications
    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: ETLPKVLEVD EKSPEAKDLL PSQTASSLCI SSRSESVWTT TPRSNWEIYR, corresponding to N terminal amino acids 4-53 of Human PIRT.

  • Positive control
    • Human kidney tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab122783 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

Target

  • Function
    Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol-4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol-4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI).
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • hCG_1776018 antibody
    • Phosphoinositide interacting regulator of transient receptor potential channels antibody
    • Phosphoinositide-interacting protein antibody
    • Pirt antibody
    • PIRT_HUMAN antibody
    see all

Images

  • Immunofluorescent staining of Human cell line A-431 shows positivity in plasma membrane and cytoplasm. Recommended concentration of ab122783 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab122783, at 1/1000 dilution, staining PIRT in Paraffin Embedded Human kidney tissue by Immunohistochemistry.

References

ab122783 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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