Overview

  • Product namePIT-1
  • Description
    PIP3/protein binding inhibitor
  • Biological descriptionPIP3/protein binding inhibitor. Specifically disrupts PIP3/Akt PH domain binding (IC50 = 31 μM); suppresses PI3K-PDK1-Akt-dependent phosphorylation. Reduces cell viability and induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM). 3,5-Dimethyl PIT-1 (ab120884) also available.
  • Purity> 98%

Properties

    References for PIT-1 (ab120885)

    This product has been referenced in:
    • Miao B  et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc Natl Acad Sci U S A 107:20126-31 (2010). Read more (PubMed: 21041639) »
    • Vivanco I & Sawyers CL The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2:489-501 (2002). Read more (PubMed: 12094235) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120885.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"