The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/40. Detects a band of approximately 31 kDa (predicted molecular weight: 33 kDa).
Use at an assay dependent dilution.
Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.
Involvement in disease
Defects in POU1F1 are the cause of pituitary hormone deficiency combined type 1 (CPHD1) [MIM:613038]. CPHD is characterized by impaired production of growth hormone (GH) and one or more of the other five anterior pituitary hormones.
Belongs to the POU transcription factor family. Class-1 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain.
Choi SY et al. Dipeptidyl peptidase-4 inhibitor gemigliptin protects against vascular calcification in an experimental chronic kidney disease and vascular smooth muscle cells. PLoS One12:e0180393 (2017).
Read more (PubMed: 28686724) »
Mancini MG et al. Subnuclear partitioning and functional regulation of the Pit-1 transcription factor. J Cell Biochem72:322-38 (1999).
Read more (PubMed: 10022514) »