Overview

  • Product name
  • Description
    Mouse monoclonal to PITRM1
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human, Recombinant fragment
  • Immunogen

    Recombinant full length Human PITRM1 protein, with a 26 kDa GST tag (AAH01150).

  • Positive control
    • Recombinant protein (immunogen) and A431 cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Monoclonal
  • Isotype
    IgG2a
  • Light chain type
    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab88342 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 125 kDa (predicted molecular weight: 117 kDa).
ELISA Use at an assay dependent dilution.

Target

  • Function
    ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
  • Tissue specificity
    Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta.
  • Sequence similarities
    Belongs to the peptidase M16 family. PreP subfamily.
  • Post-translational
    modifications
    The disulfide bond may lock the enzyme in a closed conformation under oxidized conditions, suggesting that it may participate in redox regulation of the enzyme.
  • Cellular localization
    Mitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • hMP1 antibody
    • hPreP antibody
    • KIAA1104 antibody
    • Metalloprotease 1 antibody
    • MGC138192 antibody
    • MGC141929 antibody
    • mitochondrial antibody
    • MP1 antibody
    • Pitrilysin metallopeptidase 1 antibody
    • Pitrilysin metalloproteinase 1 antibody
    • PITRM 1 antibody
    • PITRM1 antibody
    • PreP antibody
    • PreP peptidasome antibody
    • PREP_HUMAN antibody
    • Presequence protease antibody
    • Presequence protease mitochondrial antibody
    see all

Anti-PITRM1 antibody images

References for Anti-PITRM1 antibody (ab88342)

ab88342 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab88342.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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