Anti-PITX1 antibody (ab66943)

Overview

• Product name
  Anti-PITX1 antibody
  See all PITX1 primary antibodies
• Description
  Rabbit polyclonal to PITX1
• Tested applications
  Suitable for: ELISA, WBmore details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Dog
• Immunogen

  A region within synthetic peptide: GTPASPYSVY RDTCNSSLAS LRLKSKQHSS FGYGALQGPA SGLNACQYNS, corresponding to C terminal amino acids 265-314 of Human PITX1

  Run BLAST with Run BLAST with
• Positive control
  • Jurkat cell lysate

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
• Storage buffer
  Preservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• Purity
  Protein A purified
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Small G Proteins
  • Regulators

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Cancer susceptibility
  • Tumor Suppressors

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • Jurkat nuclear extract lysate (ab14844)

Applications

Target

• Function
  May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.
• Involvement in disease
  Defects in PITX1 are a cause of congenital clubfoot (CCF) [MIM:119800]; also known as talipes equinovarus (TEV). Clubfoot is a congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e. inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Clubfoot appears to be a multifactorial trait.
• Sequence similarities
  Belongs to the paired homeobox family. Bicoid subfamily.
  Contains 1 homeobox DNA-binding domain.
• Cellular localization
  Nucleus.

• Target information above from: UniProt accession P78337 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 374201 Chicken
  • Entrez Gene: 5307 Human
  • Entrez Gene: 18740 Mouse
  • Entrez Gene: 113983 Rat
  • Omim: 602149 Human
  • SwissProt: P56673 Chicken
  • SwissProt: P78337 Human
  • SwissProt: P70314 Mouse

  • SwissProt: Q99NA7 Rat
  • Unigene: 84136 Human
  • Unigene: 135195 Mouse
  • Unigene: 74248 Rat

  see all
• Alternative names
  • BFT antibody
  • CCF antibody
  • Hindlimb expressed homeobox protein backfoot antibody

  • Hindlimb-expressed homeobox protein backfoot antibody
  • Homeobox protein PITX1 antibody
  • LBNBG antibody
  • Paired like homeodomain 1 antibody
  • Paired like homeodomain transcription factor 1 antibody
  • Paired-like homeodomain transcription factor 1 antibody
  • Pituitary homeo box 1 antibody
  • Pituitary homeobox 1 antibody
  • Pituitary otx related factor antibody
  • Pitx1 antibody
  • PITX1_HUMAN antibody
  • POTX antibody
  • PTX1 antibody

  see all

Protocols

• Western blot protocols