Biological descriptionPotent, selective PARP-1 inhibitor (EC50 = 20 nM). Able to reduce both cell injury induced following deprivation of oxygen-glucose in vitro and infarct size following focal cerebral ischemia in vivo.
Chemical nameN-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide hydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Mazzone GL & Nistri A Effect of the PARP-1 inhibitor PJ 34 on excitotoxic damage evoked by kainate on rat spinal cord organotypic slices. Cell Mol Neurobiol31:469-78 (2011).
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Pacher P et al. Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure. J Pharmacol Exp Ther300:862-7 (2002).
Read more (PubMed: 11861791) »
Stone DH et al. Effect of PJ34 on spinal cord tissue viability and gene expression in a murine model of thoracic aortic reperfusion injury. Vasc Endovascular Surg43:444-51 (0).
Read more (PubMed: 19640911) »