Overview

  • Product name
    PJ34 hydrochloride
  • Description
    Potent, selective PARP-1 inhibitor
  • Biological description
    Potent, selective PARP-1 inhibitor (EC50 = 20 nM). Able to reduce both cell injury induced following deprivation of oxygen-glucose in vitro and infarct size following focal cerebral ischemia in vivo.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Mazzone GL & Nistri A Effect of the PARP-1 inhibitor PJ 34 on excitotoxic damage evoked by kainate on rat spinal cord organotypic slices. Cell Mol Neurobiol 31:469-78 (2011). Read more (PubMed: 21190076) »
  • Pacher P  et al. Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure. J Pharmacol Exp Ther 300:862-7 (2002). Read more (PubMed: 11861791) »
  • Stone DH  et al. Effect of PJ34 on spinal cord tissue viability and gene expression in a murine model of thoracic aortic reperfusion injury. Vasc Endovascular Surg 43:444-51 (0). Read more (PubMed: 19640911) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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