1/100. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
FunctionRegulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Tissue specificityFour types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Sequence similaritiesBelongs to the cAMP-dependent kinase regulatory chain family. Contains 2 cyclic nucleotide-binding domains.
Post-translational modificationsPhosphorylated by the activated catalytic chain.
Cellular localizationCytoplasm. Cell membrane. Colocalizes with PJA2 in the cytoplasm and the cell membrane.
HEK293T cells transfected with either a PKA R2 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained using ab124400 at 1/100 dilution, and then analyzed by flow cytometry.
References for Anti-PKA R2 antibody [5F1] (ab124400)
This product has been referenced in:
Hedrick ED et al. Differential PKA activation and AKAP association determines cell fate in cancer cells. J Mol Signal8:10 (2013).
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