Anti-PKC delta (phospho S664) antibody (ab78199)

Overview

  • Product nameAnti-PKC delta (phospho S664) antibody
    See all PKC delta primary antibodies
  • Description
    Rabbit polyclonal to PKC delta (phospho S664)
  • SpecificityRecognizes phospho-PKC delta (Ser664). Weaker interaction with mouse and rat PKCd (Ser662) and PKCa (Ser657) and PKCßII (Ser662).
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to amino acid region encompassing the human phospho-PKC delta (Ser664).

  • Positive control
    • RIPA lysate of PMA-treated K562 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab78199 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 78 kDa (predicted molecular weight: 78 kDa).

Target

  • FunctionThis is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin.
  • Sequence similaritiesBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 C2 domain.
    Contains 2 phorbol-ester/DAG-type zinc fingers.
    Contains 1 protein kinase domain.
  • DomainThe C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor.
    The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner.
  • Post-translational
    modifications
    Phosphorylated on Thr-507, within the activation loop. Autophosphorylated and/or phosphorylated. Although the Thr-507 phosphorylation occurs it is not a prerequisite for enzymatic activity.
  • Cellular localizationCytoplasm. Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CVID9 antibody
    • D14Ertd420e antibody
    • Kinase PKC delta antibody
    • KPCD antibody
    • KPCD_HUMAN antibody
    • MAY 1 antibody
    • MAY1 antibody
    • MGC49908 antibody
    • nPKC delta antibody
    • nPKC-delta antibody
    • PCKd antibody
    • PKC d antibody
    • PKC delta antibody
    • PKCD antibody
    • PKCdelta antibody
    • PRKC D antibody
    • PRKC delta antibody
    • Prkcd antibody
    • Protein Kinase C delta antibody
    • Protein kinase C delta type antibody
    • Protein kinase C delta VIII antibody
    • Protein Kinase Cdelta antibody
    • Tyrosine protein kinase PRKCD antibody
    see all

Anti-PKC delta (phospho S664) antibody images

  • All lanes : Anti-PKC delta (phospho S664) antibody (ab78199) at 1/1000 dilution

    Lane 1 : PMA treated K562 cell lysate
    Lane 2 : PMA treated K562 cell lysate with peptide immunogen, phospho-Ser664
    Lane 3 : PMA treated K562 cell lysate with lambda phosphatase


    Predicted band size : 78 kDa
    Observed band size : 78 kDa

References for Anti-PKC delta (phospho S664) antibody (ab78199)

ab78199 has not yet been referenced specifically in any publications.

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