Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab4135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    Western blot: 1/1000 (enhanced chemiluminescence). Predicted molecular weight: 82 kDa.
    Not tested in other applications.

    Optimal dilutions / concentrations should be determined by the end user.

    If a less sensitive detecting system, such as alkaline phosphatase, is to be employed, the dilution of the antibody should be decreased.
  • Target

    • Function
      This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.
      PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
    • Tissue specificity
      Most abundant in lung, less in heart and skin.
    • Involvement in disease
      Defects in PRKCH may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
    • Sequence similarities
      Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
      Contains 1 AGC-kinase C-terminal domain.
      Contains 1 C2 domain.
      Contains 2 phorbol-ester/DAG-type zinc fingers.
      Contains 1 protein kinase domain.
    • Domain
      The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
    • Information by UniProt
    • Database links
    • Alternative names
      • KPCL_HUMAN antibody
      • MGC 5363 antibody
      • MGC26269 antibody
      • MGC5363 antibody
      • nPKC eta antibody
      • nPKC-eta antibody
      • PKC h antibody
      • PKC L antibody
      • PKC-L antibody
      • PKCh antibody
      • PKCL antibody
      • Prkch antibody
      • PRKCL antibody
      • Protein kinase C eta antibody
      • Protein kinase C eta type antibody
      see all

    References

    ab4135 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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