Anti-PKR (phospho T446) antibody [E120] (ab32036)

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ab32036 has been referenced in 42 publications.

  • Shadle SC  et al. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet 13:e1006658 (2017). WB ; Human . PubMed: 28273136
  • Hu Z  et al. Silencing nc886, a Non-Coding RNA, Induces Apoptosis of Human Endometrial Cancer Cells-1A In Vitro. Med Sci Monit 23:1317-1324 (2017). PubMed: 28298621
  • Nakamura K  et al. Zebularine upregulates expression of CYP genes through inhibition of DNMT1 and PKR in HepG2 cells. Sci Rep 7:41093 (2017). WB . PubMed: 28112215
  • Zubovych IO  et al. A Novel Inhibitor of Topoisomerase I Is Selectively Toxic for a Subset of Non-Small Cell Lung Cancer Cell Lines. Mol Cancer Ther 15:23-36 (2016). PubMed: 26668189
  • Ziehr B  et al. Human Cytomegalovirus pTRS1 and pIRS1 Antagonize Protein Kinase R To Facilitate Virus Replication. J Virol 90:3839-48 (2016). PubMed: 26819306
  • Yuen KC  et al. NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR. Cell Rep 14:93-102 (2016). PubMed: 26725122
  • Liu R & Moss B Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants. J Virol 90:7864-79 (2016). WB ; Human . PubMed: 27334583
  • Kainulainen M  et al. NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and ß-TRCP1 To Degrade the Antiviral Protein Kinase PKR. J Virol 90:6140-7 (2016). PubMed: 27122577
  • Rabouw HH  et al. Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses. PLoS Pathog 12:e1005982 (2016). WB ; Human . PubMed: 27783669
  • Carpentier KS  et al. A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists. PLoS Pathog 12:e1005966 (2016). WB ; Human . PubMed: 27780231
  • Ravindran R  et al. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature 531:523-7 (2016). IHC . PubMed: 26982722
  • Tseng YY  et al. Regulation of PACT-Mediated Protein Kinase Activation by the OV20.0 Protein of Orf Virus. J Virol 89:11619-29 (2015). PubMed: 26355092
  • Brennan G  et al. Experimental Evolution Identifies Vaccinia Virus Mutations in A24R and A35R That Antagonize the Protein Kinase R Pathway and Accompany Collapse of an Extragenic Gene Amplification. J Virol 89:9986-97 (2015). PubMed: 26202237
  • Tseng YY  et al. Functional analysis of the short isoform of orf virus protein OV20.0. J Virol 89:4966-79 (2015). PubMed: 25694596
  • Li L  et al. Interferon-stimulated genes-essential antiviral effectors implicated in resistance to Theiler's virus-induced demyelinating disease. J Neuroinflammation 12:242 (2015). PubMed: 26703877
  • Guo C  et al. RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer. Oncotarget 6:11114-24 (2015). PubMed: 25798539
  • Pfaller CK  et al. Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R. J Virol 88:456-68 (2014). WB . PubMed: 24155404
  • Nejepinska J  et al. Reporters transiently transfected into mammalian cells are highly sensitive to translational repression induced by dsRNA expression. PLoS One 9:e87517 (2014). WB ; Human . PubMed: 24475301
  • Brennan G  et al. Adaptive gene amplification as an intermediate step in the expansion of virus host range. PLoS Pathog 10:e1004002 (2014). WB ; Human . PubMed: 24626510
  • Wen X  et al. NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells. J Immunol 192:3753-64 (2014). WB . PubMed: 24623135
  • Zhang P  et al. IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation. J Cell Sci 127:2471-82 (2014). WB . PubMed: 24659800
  • Herrero-Ruiz J  et al. ßTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy. Oncotarget 5:7563-74 (2014). PubMed: 25149538
  • Cachat A  et al. ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity. Retrovirology 11:93 (2014). PubMed: 25389016
  • Nakamura K  et al. DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis. PLoS One 8:e54036 (2013). WB ; Human . PubMed: 23320119
  • Okonski KM & Samuel CE Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1. J Virol 87:756-66 (2013). ICC/IF . PubMed: 23115276
  • Olejnik J  et al. Ebola virus does not block apoptotic signaling pathways. J Virol 87:5384-96 (2013). WB . PubMed: 23468487
  • Weiss R  et al. IL-24 sensitizes tumor cells to TLR3-mediated apoptosis. Cell Death Differ 20:823-33 (2013). PubMed: 23449395
  • Panigrahi R  et al. Interferon and ribavirin combination treatment synergistically inhibit HCV internal ribosome entry site mediated translation at the level of polyribosome formation. PLoS One 8:e72791 (2013). WB ; Human . PubMed: 24009705
  • Ng CS  et al. Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses. J Virol 87:9511-22 (2013). PubMed: 23785203
  • Cachat A  et al. Alpha interferon restricts human T-lymphotropic virus type 1 and 2 de novo infection through PKR activation. J Virol 87:13386-96 (2013). PubMed: 24089560
  • Gantke T  et al. Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-?B1 p105 complex in co-transfected HEK-293 cells. Biochem J 452:359-65 (2013). PubMed: 23557442
  • Treppendahl MB  et al. Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML. Blood 119:206-16 (2012). WB ; Human . PubMed: 22058117
  • He Y  et al. The role of PKR/eIF2a signaling pathway in prognosis of non-small cell lung cancer. PLoS One 6:e24855 (2011). WB ; Human . PubMed: 22102852
  • Peidis P  et al. Doxorubicin bypasses the cytoprotective effects of eIF2a phosphorylation and promotes PKR-mediated cell death. Cell Death Differ 18:145-54 (2011). WB ; Human . PubMed: 20559319
  • Kang JI & Ahn BY HCV-induced PKR activation is stimulated by the mitogen- and stress-activated protein kinase MSK2. Biochem Biophys Res Commun 407:248-53 (2011). WB ; Human . PubMed: 21385567
  • Lee K  et al. Precursor miR-886, a novel noncoding RNA repressed in cancer, associates with PKR and modulates its activity. RNA 17:1076-89 (2011). PubMed: 21518807
  • Sharma B  et al. Protein Kinase R as Mediator of the Effects of Interferon (IFN) {gamma} and Tumor Necrosis Factor (TNF) {alpha} on Normal and Dysplastic Hematopoiesis. J Biol Chem 286:27506-14 (2011). PubMed: 21659535
  • von Roretz C & Gallouzi IE Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR). J Biol Chem 285:16806-13 (2010). WB ; Human . PubMed: 20353946
  • Russell ST & Tisdale MJ Mechanism of attenuation of skeletal muscle atrophy by zinc-alpha2-glycoprotein. Endocrinology 151:4696-704 (2010). WB ; Mouse . PubMed: 20702573
  • Mounir Z  et al. Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. Sci Signal 2:ra85 (2009). ICC/IF ; Mouse . PubMed: 20029030
  • Goggin K  et al. Prion protein aggresomes are poly(A)+ ribonucleoprotein complexes that induce a PKR-mediated deficient cell stress response. Biochim Biophys Acta 1783:479-91 (2008). PubMed: 18023289
  • Musner N  et al. Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy. ASN Neuro 8:N/A (0). WB . PubMed: 27095827


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