Overview

  • Product nameAnti-PLA2G4D antibody
    See all PLA2G4D primary antibodies
  • Description
    Rabbit polyclonal to PLA2G4D
  • SpecificityDetects endogenous levels of total PLA2G4D protein.
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from an internal sequence of Human PLA2G4D.

  • Positive control
    • Human brain tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab111126 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionCalcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.
  • Tissue specificityExpressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin.
  • Sequence similaritiesContains 1 C2 domain.
    Contains 1 PLA2c domain.
  • DomainThe N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
  • Cellular localizationCytoplasm > cytosol. Cytoplasmic vesicle membrane. Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation.
  • Information by UniProt
  • Database links
  • Alternative names
    • cPLA2 delta antibody
    • cPLA2-delta antibody
    • cPLA2delta antibody
    • Cytosolic phospholipase A2 delta antibody
    • PA24D_HUMAN antibody
    • Phospholipase A2 group IVD antibody
    • phospholipase A2, group IVD (cytosolic) antibody
    • Pla2g4d antibody
    see all

Anti-PLA2G4D antibody images

  • ab111126, at a 1/50 dilution, staining PLA2G4D in paraffin embedded Human brain tissue by Immunohistochemistry. The image on the right is from cells treated with the synthesized peptide.

References for Anti-PLA2G4D antibody (ab111126)

ab111126 has not yet been referenced specifically in any publications.

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