Anti-PLAC1 antibody (ab105395)
Key features and details
- Rabbit polyclonal to PLAC1
- Suitable for: WB, ICC
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-PLAC1 antibody
See all PLAC1 primary antibodies -
Description
Rabbit polyclonal to PLAC1 -
Host species
Rabbit -
Specificity
ab105395 is predicted not to cross-react with other PLAC family protein members. -
Tested applications
Suitable for: WB, ICCmore details -
Species reactivity
Reacts with: Human -
Immunogen
A 15 amino acid synthetic peptide from near the carboxy terminus of Human PLAC1 (NP_068568).
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Positive control
- Human placenta tissue lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab105395 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 24 kDa.
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ICC |
Use a concentration of 10 - 20 µg/ml.
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Notes |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 24 kDa. |
ICC
Use a concentration of 10 - 20 µg/ml. |
Target
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Function
May play a role in placental development. -
Tissue specificity
Expressed in placenta. Localizes primarily to differentiated syncytiotrophoblast throughout gestation as well as to a small population of villous cytotrophoblasts. Also detected in maternal blood and rapidly disappears following delivery, but is not detected in other adult or fetal tissues examined. -
Sequence similarities
Belongs to the PLAC1 family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 10761 Human
- Omim: 300296 Human
- SwissProt: Q9HBJ0 Human
- Unigene: 496811 Human
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Alternative names
- Cancer/testis antigen 92 antibody
- CT92 antibody
- Plac1 antibody
see all
Images
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All lanes : Anti-PLAC1 antibody (ab105395) at 1 µg/ml
Lane 1 : Human placenta tissue lysate
Lane 2 : Human placenta tissue lysate with blocking peptide
Lysates/proteins at 15 µg per lane.
Predicted band size: 24 kDa -
Immunocytochemistry of PLAC1 in HeLa cells with ab105395 at 10 µg/ml.
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Immunofluorescence of PLAC1 in Hela cells using ab105395 at 20 ug/ml.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab105395 has been referenced in 5 publications.
- Sun D et al. PLAC1 Regulates the Occurrence of Fetal Growth Restriction by Inhibiting the Apoptosis of Trophoblast Cells. Ann Clin Lab Sci 51:182-189 (2021). PubMed: 33941557
- Wan L et al. Declined placental PLAC1 expression is involved in preeclampsia. Medicine (Baltimore) 98:e17676 (2019). PubMed: 31689783
- Li Q et al. PLAC1-specific TCR-engineered T cells mediate antigen-specific antitumor effects in breast cancer. Oncol Lett 15:5924-5932 (2018). PubMed: 29556312
- Gormley M et al. Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations. Am J Obstet Gynecol 217:200.e1-200.e17 (2017). PubMed: 28347715
- Chang WL et al. Role of placenta-specific protein 1 in trophoblast invasion and migration. Reproduction 148:343-52 (2014). PubMed: 24989904